Deep hypometabolic state mitigates radiation-induced lethality in zebrafish
نویسندگان
چکیده
منابع مشابه
Curcumin Mitigates Radiation-induced Lung Pneumonitis and Fibrosis in Rats
Radiation-induced lung injury is one of the most prominent factors that interfere with chest cancer radiotherapy, and poses a great threat to patients exposed to total body irradiation. Upregulation of pro-oxidant enzymes is one of the main mechanisms through which the late effects of ionizing radiation on lung injury can be exerted. Interleukin (IL)-4 and IL-13 are two important cytokines that...
متن کاملNRF2 mitigates radiation-induced hematopoietic death.
Fractionated, high-dose total body irradiation (TBI) is used therapeutically to myeloablate and immune suppress patients undergoing hematopoietic stem cell (HSC) transplantation. Acute exposure to ionizing radiation can have fatal effects on the hematopoietic and immune systems. Currently, therapies aimed at ameliorating ionizing radiation-associated toxicities are limited. In the February 2014...
متن کاملA wakeful hypometabolic physiologic state.
WALLACE ROBERT KEITH HERBERT BENSON, AND ARCHIE F. WILSON. A kzkeful h@mwtabtkc pI$iologic state, Am. J. Physiol. 22 l(3) : 795-799. 197 1 .-Mental states can markedly alter physiologic function. Hypermetabolic physiologic states, with in creased oxygen consumption, accompany anticipated stressful situations. Hypometabolic physiologic changes, other than those occurring during sleep and hiberna...
متن کاملEvaluation of Radio-Protective Effects of N-Acetylcysteine on Radiation-Induced Lethality in Mice
Introduction It has long been known that ionizing radiation can lead to detrimental effects in normal cells. In this light, Radioprotective chemicals have been used to decrease morbidity or mortality caused by ionizing irradiation. This study aimed to evaluate the radio-protective effect of N-acetylcysteineagainst radiation-induced mortality in male mice. Materials and Methods 52 healthy mal...
متن کاملAllopurinol gel mitigates radiation-induced mucositis and dermatitis.
It has not been verified whether allopurinol application is beneficial in decreasing the severity of radiation-induced oral mucositis and dermatitis. Rats were divided into 4 groups and received 15 Gy irradiation on the left whisker pad. Group 1 received only irradiation. Group 2 was maintained by applying allopurinol/carrageenan-mixed gel (allopurinol gel) continuously from 2 days before to 20...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomedical Research and Clinical Practice
سال: 2017
ISSN: 2397-9631
DOI: 10.15761/brcp.1000139